IGF-1 LR3 Research Peptide, US-Made & Third-Party Tested
✓ US-made · third-party tested · free US shipping over $100
last updated · reviewed by the verve research team
what is igf-1 lr3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
That reduced binding-protein affinity is the reason IGF-1 LR3 is widely used as a supplement in cell-culture media and as a reference ligand in IGF-1-receptor signaling research, where free-ligand availability would otherwise be difficult to control. Verve manufactures IGF-1 LR3 in the United States, tests every batch to a high-purity research standard, and publishes a batch-level certificate of analysis.
igf-1 lr3 specifications
Reference data for IGF-1 LR3 as supplied by verve for laboratory research use only.
| Compound | IGF-1 LR3 |
|---|---|
| Compound class | Recombinant IGF-1 analog polypeptide |
| Research area | longevity & cellular |
| Primary research focus | receptor-signaling research |
| Purity standard | High-purity research standard, third-party tested per batch |
| Supplied as | Single research compound |
| Endotoxin-tested option | Available |
| Catalog sizes | 1mg · 2x 1mg |
| Catalog price | from $93 |
| Availability | Out of stock |
| Intended use | In-vitro laboratory research use only. Not for human or veterinary use. |
| Reference last reviewed |
what is igf-1 lr3 used for in research?
IGF-1 LR3 is supplied strictly for laboratory research use only. Reported research contexts include:
- IGF-1 receptor binding and signal-transduction research
- PI3K/Akt and MAPK pathway research in cellular models
- Cell-culture media supplementation for proliferation research
- IGFBP interaction and free-ligand availability studies
- Comparative analog research against native IGF-1
how pure is igf-1 lr3?
purity, third-party testing & the certificate of analysis
Every batch of verve IGF-1 LR3is synthesized and vial-filled in the United States and screened by an independent, accredited laboratory. Chromatographic purity and quantity are measured by HPLC-UV/VIS; where the panel includes them, endotoxin is screened by LAL and sterility by USP <71>, with the sterility result reported as no growth detected or as pending while the culture is still running. Products are manufactured to a 99%+ purity standard where stated.
Published certificates for the lots currently in our COA library cover part of the range; a published report for this compound is not in the library yet. Orders placed Monday–Friday ship by 2pm CT, free over $100, with damage protection in transit and full US tracking.
IGF-1 LR3, explained in 60 secondsthe plain-english version — what it is, where it shows up, and the lab report behind the vialigf-1 lr3 frequently asked questions
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
What is IGF-1 LR3 studied for in research?
It is used as a reference ligand in IGF-1-receptor binding and downstream signal-transduction research, and as a cell-culture supplement in proliferation studies. Verve makes no claims about effects in humans or animals.
How pure is Verve's IGF-1 LR3, and is a COA included?
It is US-made, prepared and tested to a high-purity research standard, and shipped with a downloadable batch-level certificate of analysis matched to your vial's batch code.
igf-1 lr3 research references
- White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, et al. IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep. Am J Physiol Endocrinol Metab. 2025;328(1):E116-E125.Tested growth and metabolic endpoints in a late-gestation growth-restricted fetal sheep model and reported a null result.
- Laajoki LG, Le Breton E, Shooter GK, Wallace JC, Francis GL, Carver JA, et al. Secondary structure determination of 15N-labelled human Long-[Arg-3]-insulin-like growth factor 1 by multidimensional NMR spectroscopy. FEBS Lett. 1997;420(1):97-102.Determined the solution secondary structure of Long-[Arg3]-IGF-1 by multidimensional NMR on the 15N-labelled analogue.
- Conlon MA, Tomas FM, Owens PC, Wallace JC, Howarth GS, Ballard FJ. Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig. J Endocrinol. 1995;146(2):247-53.Measured organ-mass and circulating IGF/IGFBP endpoints during Long R3 IGF-I infusion in a guinea pig model.
- King R, Wells JR, Krieg P, Snoswell M, Brazier J, Bagley CJ, et al. Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu3, following their expression in Escherichia coli as fusion proteins. J Mol Endocrinol. 1992;8(1):29-41.Described recombinant production and in-vitro characterisation of the Glu3-substituted IGF-I analogues that define the R3 modification.
- Francis GL, Ross M, Ballard FJ, Milner SJ, Senn C, McNeil KA, et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. J Mol Endocrinol. 1992;8(3):213-23.Dissected the relative contributions of IGF-binding-protein affinity versus receptor binding to analogue potency in cell-based assays.
research areas igf-1 lr3 appears in
igf-1 lr3 vs other research compounds
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US-made, third-party tested research peptides, every vial batch-traceable, every COA one click away.
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.