IGF-1 LR3 vs Ipamorelin
IGF-1 LR3 and Ipamorelin are both studied in longevity research, but they are different classes of compound with different reported research applications.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do IGF-1 LR3 and Ipamorelin differ?
IGF-1 LR3 (Recombinant IGF-1 analog polypeptide) is catalogued under longevity & cellular research; Ipamorelin (Synthetic pentapeptide secretagogue) is catalogued under longevity & cellular research. Verve lists 5 reported research applications for IGF-1 LR3 and 5 for Ipamorelin. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | IGF-1 LR3 | Ipamorelin |
|---|---|---|
| compound class | Recombinant IGF-1 analog polypeptide | Synthetic pentapeptide secretagogue |
| research area | longevity & cellular | longevity & cellular |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 1mg · 2x 1mg | 5mg · 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $93.49 | $64.99 |
| availability | out of stock | out of stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is IGF-1 LR3 and what is Ipamorelin?
IGF-1 LR3 is classified as Recombinant IGF-1 analog polypeptide; Ipamorelin as Synthetic pentapeptide secretagogue. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →Ipamorelin
Synthetic pentapeptide secretagogue
Ipamorelin is a synthetic pentapeptide and a selective growth-hormone secretagogue, meaning it is characterized in the literature as an agonist at the growth-hormone secretagogue receptor (GHS-R1a), the same receptor targeted by the endogenous ligand ghrelin. Its selectivity profile is the reason it is so frequently chosen as a reference agonist in receptor-signaling work.
full Ipamorelin profile →Which research models is each compound studied in?
IGF-1 LR3 and Ipamorelin both sit inside longevity & cellular research, so their listed models share framing while differing in specifics. The table lists 5 reported research applications for IGF-1 LR3 and 5 for Ipamorelin. Rows are per compound, not equivalences.
| IGF-1 LR3 — reported research applications | Ipamorelin — reported research applications |
|---|---|
| IGF-1 receptor binding and signal-transduction research | GHS-R1a (ghrelin receptor) binding and agonist research |
| PI3K/Akt and MAPK pathway research in cellular models | Secretagogue-pathway signal-transduction research |
| Cell-culture media supplementation for proliferation research | Comparative receptor-selectivity studies against non-selective secretagogues |
| IGFBP interaction and free-ligand availability studies | Endocrine-signaling research models |
| Comparative analog research against native IGF-1 | Peptide stability and structure–activity research |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for IGF-1 LR3 and Ipamorelin?
IGF-1 LR3 is listed from $93.49 and Ipamorelin from $64.99. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| IGF-1 LR3 | 1mg | $93.49 | out of stock |
| IGF-1 LR3 | 2x 1mg | $171.49 | out of stock |
| Ipamorelin | 5mg | $64.99 | out of stock |
| Ipamorelin | 10mg | $114.49 | out of stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about IGF-1 LR3 and Ipamorelin
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide characterized as a selective agonist at the growth-hormone secretagogue receptor (GHS-R1a). Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is Ipamorelin studied for in research?
It is used as a reference agonist in GHS-R1a receptor-binding and secretagogue-pathway signaling research in in-vitro and pre-clinical models. Verve makes no claims about effects in humans or animals.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.