Epitalon vs IGF-1 LR3
Epitalon and IGF-1 LR3 are both studied in longevity research, but they are different classes of compound with different reported research applications.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do Epitalon and IGF-1 LR3 differ?
Epitalon (Synthetic tetrapeptide) is catalogued under longevity & cellular research; IGF-1 LR3 (Recombinant IGF-1 analog polypeptide) is catalogued under longevity & cellular research. Verve lists 5 reported research applications for Epitalon and 5 for IGF-1 LR3. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | Epitalon | IGF-1 LR3 |
|---|---|---|
| compound class | Synthetic tetrapeptide | Recombinant IGF-1 analog polypeptide |
| research area | longevity & cellular | longevity & cellular |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 10mg · 50mg | 1mg · 2x 1mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | not offered | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $50.49 | $93.49 |
| availability | out of stock | out of stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is Epitalon and what is IGF-1 LR3?
Epitalon is classified as Synthetic tetrapeptide; IGF-1 LR3 as Recombinant IGF-1 analog polypeptide. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
Epitalon
Synthetic tetrapeptide
Epitalon is a synthetic tetrapeptide with the sequence alanyl-glutamyl-aspartyl-glycine (Ala-Glu-Asp-Gly), developed as a short synthetic analog of a peptide fraction isolated from the pineal gland. It is a small, water-soluble peptide and one of the most frequently cited reference compounds in pineal-peptide and cellular-aging research literature.
full Epitalon profile →IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →Which research models is each compound studied in?
Epitalon and IGF-1 LR3 both sit inside longevity & cellular research, so their listed models share framing while differing in specifics. The table lists 5 reported research applications for Epitalon and 5 for IGF-1 LR3. Rows are per compound, not equivalences.
| Epitalon — reported research applications | IGF-1 LR3 — reported research applications |
|---|---|
| Telomerase-expression research models | IGF-1 receptor binding and signal-transduction research |
| Pineal-peptide and circadian-signaling research | PI3K/Akt and MAPK pathway research in cellular models |
| Chromatin and gene-regulation studies | Cell-culture media supplementation for proliferation research |
| Cellular-senescence and replicative-aging research models | IGFBP interaction and free-ligand availability studies |
| Short-peptide stability and synthesis research | Comparative analog research against native IGF-1 |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for Epitalon and IGF-1 LR3?
Epitalon is listed from $50.49 and IGF-1 LR3 from $93.49. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| Epitalon | 10mg | $50.49 | out of stock |
| Epitalon | 50mg | $64.99 | out of stock |
| IGF-1 LR3 | 1mg | $93.49 | out of stock |
| IGF-1 LR3 | 2x 1mg | $171.49 | out of stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about Epitalon and IGF-1 LR3
What is Epitalon?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a peptide fraction identified in the pineal gland. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is Epitalon studied for in research?
In in-vitro and pre-clinical research it is used as a reference compound in telomerase-expression, gene-regulation, cellular-senescence, and pineal-peptide signaling models. Verve makes no claims about use in humans or animals.
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
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verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.