Epitalon Research Peptide, US-Made & Third-Party Tested
✓ US-made · third-party tested · free US shipping over $100
last updated · reviewed by the verve research team
what is epitalon?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a peptide fraction identified in the pineal gland. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use. It is catalogued under longevity & cellular as a synthetic tetrapeptide.
Epitalon is a synthetic tetrapeptide with the sequence alanyl-glutamyl-aspartyl-glycine (Ala-Glu-Asp-Gly), developed as a short synthetic analog of a peptide fraction isolated from the pineal gland. It is a small, water-soluble peptide and one of the most frequently cited reference compounds in pineal-peptide and cellular-aging research literature.
In the laboratory, Epitalon is studied in telomerase-expression models, chromatin and gene-regulation research, and work on circadian and pineal peptide signaling in cell culture and pre-clinical systems. Because reproducibility in this research depends on knowing exactly what is in the vial, verve manufactures Epitalon in the United States, screens every batch by HPLC to a 99%+ purity standard, and publishes a batch-level certificate of analysis.
epitalon specifications
Reference data for Epitalon as supplied by verve for laboratory research use only.
| Compound | Epitalon |
|---|---|
| Compound class | Synthetic tetrapeptide |
| Research area | longevity & cellular |
| Primary research focus | telomerase & pineal-peptide research |
| Purity standard | 99%+ purity standard, HPLC-verified per batch |
| Supplied as | Single research compound |
| Endotoxin-tested option | Not offered |
| Catalog sizes | 10mg · 50mg |
| Catalog price | from $50 |
| Availability | Out of stock |
| Intended use | In-vitro laboratory research use only. Not for human or veterinary use. |
| Reference last reviewed |
what is epitalon used for in research?
Epitalon is supplied strictly for laboratory research use only. Reported research contexts include:
- Telomerase-expression research models
- Pineal-peptide and circadian-signaling research
- Chromatin and gene-regulation studies
- Cellular-senescence and replicative-aging research models
- Short-peptide stability and synthesis research
how pure is epitalon?
purity, third-party testing & the certificate of analysis
Every batch of verve Epitalonis synthesized and vial-filled in the United States and screened by an independent, accredited laboratory. Chromatographic purity and quantity are measured by HPLC-UV/VIS; where the panel includes them, endotoxin is screened by LAL and sterility by USP <71>, with the sterility result reported as no growth detected or as pending while the culture is still running. Products are manufactured to a 99%+ purity standard where stated.
Published certificates for the lots currently in our COA library cover part of the range; a published report for this compound is not in the library yet. Orders placed Monday–Friday ship by 2pm CT, free over $100, with damage protection in transit and full US tracking.
Epitalon, explained in 60 secondsthe plain-english version — what it is, where it shows up, and the lab report behind the vialepitalon frequently asked questions
What is Epitalon?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a peptide fraction identified in the pineal gland. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is Epitalon studied for in research?
In in-vitro and pre-clinical research it is used as a reference compound in telomerase-expression, gene-regulation, cellular-senescence, and pineal-peptide signaling models. Verve makes no claims about use in humans or animals.
How pure is Verve's Epitalon?
It is manufactured in the US to a 99%+ purity standard and verified by HPLC on every batch, with third-party testing on each lot.
Is a certificate of analysis included?
Yes, every order includes a downloadable batch-level COA. Match the batch code on your vial to the row in the COA library to read the report for your exact lot.
epitalon research references
- Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178.Measured telomere length and telomerase versus alternative-lengthening-of-telomeres pathway activity in human cell lines in culture.
- Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6).Peer-reviewed review cataloguing the published in-vitro and animal literature on the AEDG tetrapeptide.
- Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, et al. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY). 2022;14(7):3191-3202.Examined post-ovulatory aging markers in cultured mouse oocytes in vitro.
- Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3).Profiled gene expression and protein-synthesis markers in a cell-culture neurogenesis model.
- Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev. 2000;120(1-3):141-9.Recorded lifespan distributions in a Drosophila melanogaster invertebrate aging model.
research areas epitalon appears in
epitalon vs other research compounds
all comparisons →research compounds related to epitalon
purity, proven.
US-made, third-party tested research peptides, every vial batch-traceable, every COA one click away.
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.