MOTS-C Research Peptide, US-Made & Third-Party Tested
✓ US-made · third-party tested · free US shipping over $100
last updated · reviewed by the verve research team
what is mots-c?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use. It is catalogued under weight & metabolic as a mitochondrial-derived 16-amino-acid peptide.
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
In cellular and pre-clinical models, MOTS-c is studied as a reference compound in mitochondrial-signaling research, including work on the AMPK pathway, folate–methionine one-carbon metabolism, and nuclear translocation of mitochondrially encoded peptides under metabolic stress. Verve manufactures MOTS-c in the United States, screens every batch by HPLC to a 99%+ purity standard, and publishes a batch-level certificate of analysis.
mots-c specifications
Reference data for MOTS-C as supplied by verve for laboratory research use only.
| Compound | MOTS-C |
|---|---|
| Compound class | Mitochondrial-derived 16-amino-acid peptide |
| Research area | weight & metabolic |
| Primary research focus | cellular-metabolism research |
| Purity standard | 99%+ purity standard, HPLC-verified per batch |
| Supplied as | Single research compound |
| Endotoxin-tested option | Available |
| Catalog sizes | 10mg |
| Catalog price | from $79 |
| Availability | In stock |
| Intended use | In-vitro laboratory research use only. Not for human or veterinary use. |
| Reference last reviewed |
what is mots-c used for in research?
MOTS-C is supplied strictly for laboratory research use only. Reported research contexts include:
- Mitochondrial-derived peptide and retrograde-signaling research
- AMPK pathway research models
- One-carbon (folate–methionine) metabolism studies
- Cellular energy-metabolism and substrate-utilization research
- Exercise-physiology and metabolic-stress research models
how pure is mots-c?
purity, third-party testing & the certificate of analysis
Every batch of verve MOTS-Cis synthesized and vial-filled in the United States and screened by an independent, accredited laboratory. Chromatographic purity and quantity are measured by HPLC-UV/VIS; where the panel includes them, endotoxin is screened by LAL and sterility by USP <71>, with the sterility result reported as no growth detected or as pending while the culture is still running. Products are manufactured to a 99%+ purity standard where stated.
That lab report is the certificate of analysis. Match the batch code printed on your vial to the row in our COA library and you're reading the exact report for the exact vial in your hand. This compound's current report covers lot 3548249, published 2026-05-27. Orders placed Monday–Friday ship by 2pm CT, free over $100, with damage protection in transit and full US tracking.
MOTS-C, explained in 60 secondsthe plain-english version — what it is, where it shows up, and the lab report behind the vialwhere to buy mots-c for research
MOTS-Cweight & metabolicfrom $79browse all weight & metabolic →mots-c frequently asked questions
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
Why is MOTS-C called a mitochondrial-derived peptide?
Because its coding sequence lies within mitochondrial DNA rather than nuclear DNA. That unusual origin is a large part of why it is studied as a model compound in cellular-metabolism research.
How pure is Verve's MOTS-C, and is a COA included?
It is US-made, verified by HPLC to a 99%+ purity standard, and third-party tested, with a downloadable batch-level COA on every order matched to your vial's batch code.
mots-c research references
- Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, et al. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021;320(4):E680-E690.Examined myostatin expression and atrophy-related signalling pathways in pre-clinical skeletal-muscle models.
- Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, et al. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. J Mol Med (Berl). 2019;97(4):473-485.Examined adipose-tissue signalling and metabolic parameters in an ovariectomised rodent model of metabolic dysfunction.
- Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018;28(3):516-524.e7.Examined nuclear translocation of the peptide and the nuclear gene-expression programmes engaged under metabolic-stress conditions in cellular models.
- Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-54.Identified the 12S rRNA-encoded peptide and examined folate-cycle inhibition, AICAR accumulation and AMPK activation in cultured cells and high-fat-diet mouse models.
research areas mots-c appears in
mots-c vs other research compounds
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purity, proven.
US-made, third-party tested research peptides, every vial batch-traceable, every COA one click away.
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.