5-Amino-1MQ vs MOTS-C
5-Amino-1MQ and MOTS-C are both studied in weight research, but they are different classes of compound with different reported research applications.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do 5-Amino-1MQ and MOTS-C differ?
5-Amino-1MQ (Small-molecule enzyme inhibitor (not a peptide)) is catalogued under weight & metabolic research; MOTS-C (Mitochondrial-derived 16-amino-acid peptide) is catalogued under weight & metabolic research. Verve lists 5 reported research applications for 5-Amino-1MQ and 5 for MOTS-C. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | 5-Amino-1MQ | MOTS-C |
|---|---|---|
| compound class | Small-molecule enzyme inhibitor (not a peptide) | Mitochondrial-derived 16-amino-acid peptide |
| research area | weight & metabolic | weight & metabolic |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 10mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | not offered | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $114.49 | $78.99 |
| availability | in stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is 5-Amino-1MQ and what is MOTS-C?
5-Amino-1MQ is classified as Small-molecule enzyme inhibitor (not a peptide); MOTS-C as Mitochondrial-derived 16-amino-acid peptide. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
5-Amino-1MQ
Small-molecule enzyme inhibitor (not a peptide)
5-Amino-1MQ is a small molecule rather than a peptide: a methylquinolinium compound that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is cell-permeable and carries a permanent positive charge on its quaternary nitrogen, a structural feature that shapes how it distributes in cellular assays and why it is used as a tool compound in enzyme-inhibition research.
full 5-Amino-1MQ profile →MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →Which research models is each compound studied in?
5-Amino-1MQ and MOTS-C both sit inside weight & metabolic research, so their listed models share framing while differing in specifics. The table lists 5 reported research applications for 5-Amino-1MQ and 5 for MOTS-C. Rows are per compound, not equivalences.
| 5-Amino-1MQ — reported research applications | MOTS-C — reported research applications |
|---|---|
| NNMT enzyme-inhibition and kinetics research | Mitochondrial-derived peptide and retrograde-signaling research |
| NAD+ salvage-pathway and nicotinamide-metabolism studies | AMPK pathway research models |
| S-adenosylmethionine and methyl-donor balance research | One-carbon (folate–methionine) metabolism studies |
| Adipocyte and cellular energy-metabolism research models | Cellular energy-metabolism and substrate-utilization research |
| Small-molecule structure–activity and selectivity studies | Exercise-physiology and metabolic-stress research models |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for 5-Amino-1MQ and MOTS-C?
5-Amino-1MQ is listed from $114.49 and MOTS-C from $78.99. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| 5-Amino-1MQ | 10mg | $114.49 | in stock |
| MOTS-C | 10mg | $78.99 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about 5-Amino-1MQ and MOTS-C
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule, not a peptide — a methylquinolinium compound that selectively inhibits the enzyme nicotinamide N-methyltransferase (NNMT). Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule enzyme inhibitor with no amino-acid backbone, which is why it is handled and stored differently from the peptides in the catalog. It is supplied strictly for laboratory research.
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
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verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.