5-Amino-1MQ Research Peptide, US-Made & Third-Party Tested
✓ US-made · third-party tested · free US shipping over $100
last updated · reviewed by the verve research team
what is 5-amino-1mq?
5-Amino-1MQ is a small molecule, not a peptide — a methylquinolinium compound that selectively inhibits the enzyme nicotinamide N-methyltransferase (NNMT). Verve supplies it as a research compound for laboratory use only, not for human or veterinary use. It is catalogued under weight & metabolic as a small-molecule enzyme inhibitor (not a peptide).
5-Amino-1MQ is a small molecule rather than a peptide: a methylquinolinium compound that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is cell-permeable and carries a permanent positive charge on its quaternary nitrogen, a structural feature that shapes how it distributes in cellular assays and why it is used as a tool compound in enzyme-inhibition research.
NNMT sits at a junction between nicotinamide handling and the methyl-donor pool, so 5-Amino-1MQ is studied in vitro and in pre-clinical models as a probe of NNMT enzyme kinetics, NAD+ salvage-pathway flux, and S-adenosylmethionine methylation balance. Verve manufactures 5-Amino-1MQ in the United States, screens every batch to a high-purity research standard, and publishes a batch-level certificate of analysis.
5-amino-1mq specifications
Reference data for 5-Amino-1MQ as supplied by verve for laboratory research use only.
| Compound | 5-Amino-1MQ |
|---|---|
| Compound class | Small-molecule enzyme inhibitor (not a peptide) |
| Research area | weight & metabolic |
| Primary research focus | enzyme-inhibition research |
| Purity standard | High-purity research standard, third-party tested per batch |
| Supplied as | Single research compound |
| Endotoxin-tested option | Not offered |
| Catalog sizes | 10mg |
| Catalog price | from $114 |
| Availability | In stock |
| Intended use | In-vitro laboratory research use only. Not for human or veterinary use. |
| Reference last reviewed |
what is 5-amino-1mq used for in research?
5-Amino-1MQ is supplied strictly for laboratory research use only. Reported research contexts include:
- NNMT enzyme-inhibition and kinetics research
- NAD+ salvage-pathway and nicotinamide-metabolism studies
- S-adenosylmethionine and methyl-donor balance research
- Adipocyte and cellular energy-metabolism research models
- Small-molecule structure–activity and selectivity studies
how pure is 5-amino-1mq?
purity, third-party testing & the certificate of analysis
Every batch of verve 5-Amino-1MQis synthesized and vial-filled in the United States and screened by an independent, accredited laboratory. Chromatographic purity and quantity are measured by HPLC-UV/VIS; where the panel includes them, endotoxin is screened by LAL and sterility by USP <71>, with the sterility result reported as no growth detected or as pending while the culture is still running. Products are manufactured to a 99%+ purity standard where stated.
Published certificates for the lots currently in our COA library cover part of the range; a published report for this compound is not in the library yet. Orders placed Monday–Friday ship by 2pm CT, free over $100, with damage protection in transit and full US tracking.
5-Amino-1MQ, explained in 60 secondsthe plain-english version — what it is, where it shows up, and the lab report behind the vialwhere to buy 5-amino-1mq for research
5-Amino-1MQweight & metabolicfrom $114browse all weight & metabolic →5-amino-1mq frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule, not a peptide — a methylquinolinium compound that selectively inhibits the enzyme nicotinamide N-methyltransferase (NNMT). Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule enzyme inhibitor with no amino-acid backbone, which is why it is handled and stored differently from the peptides in the catalog. It is supplied strictly for laboratory research.
What is 5-Amino-1MQ studied for in research?
It is used as a tool compound in NNMT enzyme-inhibition research, NAD+ salvage-pathway studies, and methyl-donor metabolism models in vitro and pre-clinically. Verve makes no claims about use in humans or animals.
How pure is Verve's 5-Amino-1MQ, and is a COA included?
It is US-made, prepared and screened to a high-purity research standard, and third-party tested, with a downloadable batch-level certificate of analysis on every order.
5-amino-1mq research references
- Dimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022;12(1):484.Profiled gut-microbiome composition in diet-induced-obese mice under NNMT inhibition with caloric restriction.
- Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci Rep. 2021;11(1):5637.Examined body-composition and metabolic parameters in obese mice under NNMT inhibition combined with a reduced-calorie diet.
- Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492.Examined satellite-cell activity and regeneration markers in aged mouse skeletal muscle following small-molecule NNMT inhibition.
- Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.Characterised enzyme selectivity and cell permeability of methylquinolinium NNMT inhibitors and measured adiposity and metabolic endpoints in diet-induced-obese mice.
- Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60(12):5015-5028.Mapped structure-activity relationships across a methylquinolinium series of NNMT inhibitors and measured enzyme-inhibition potency in vitro.
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US-made, third-party tested research peptides, every vial batch-traceable, every COA one click away.
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.