IGF-1 LR3 vs TB-500
IGF-1 LR3 and TB-500 come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do IGF-1 LR3 and TB-500 differ?
IGF-1 LR3 (Recombinant IGF-1 analog polypeptide) is catalogued under longevity & cellular research; TB-500 (Thymosin β4 fragment · tissue-repair research) is catalogued under recovery & gut research. Verve lists 5 reported research applications for IGF-1 LR3 and 4 for TB-500. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | IGF-1 LR3 | TB-500 |
|---|---|---|
| compound class | Recombinant IGF-1 analog polypeptide | Thymosin β4 fragment · tissue-repair research |
| research area | longevity & cellular | recovery & gut |
| reported research applications | 5 listed | 4 listed |
| supplied as | single compound | single compound |
| catalog sizes | 1mg · 2x 1mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $93.49 | $93.49 |
| availability | out of stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is IGF-1 LR3 and what is TB-500?
IGF-1 LR3 is classified as Recombinant IGF-1 analog polypeptide; TB-500 as Thymosin β4 fragment · tissue-repair research. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →TB-500
Thymosin β4 fragment · tissue-repair research
TB-500 is a synthetic 43-amino-acid peptide corresponding to an active fragment of thymosin beta-4, a naturally-occurring actin-binding protein. Verve supplies it as a high-purity research compound for tissue-repair and cellular research.
full TB-500 profile →Which research models is each compound studied in?
IGF-1 LR3 sits in longevity & cellular research and TB-500 in recovery & gut research, so their listed models largely do not intersect. The table lists 5 reported research applications for IGF-1 LR3 and 4 for TB-500. Rows are per compound, not equivalences.
| IGF-1 LR3 — reported research applications | TB-500 — reported research applications |
|---|---|
| IGF-1 receptor binding and signal-transduction research | Cell-migration research models |
| PI3K/Akt and MAPK pathway research in cellular models | Actin-regulation and cytoskeletal research |
| Cell-culture media supplementation for proliferation research | Angiogenesis research |
| IGFBP interaction and free-ligand availability studies | Tissue-repair research models |
| Comparative analog research against native IGF-1 | — |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for IGF-1 LR3 and TB-500?
IGF-1 LR3 is listed from $93.49 and TB-500 from $93.49. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| IGF-1 LR3 | 1mg | $93.49 | out of stock |
| IGF-1 LR3 | 2x 1mg | $171.49 | out of stock |
| TB-500 | 10mg | $93.49 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about IGF-1 LR3 and TB-500
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
What is TB-500?
TB-500 is a synthetic 43-amino-acid peptide based on an active fragment of thymosin beta-4. Verve supplies it as a research compound for laboratory use only.
What is TB-500 studied for in research?
It is used in cell-migration, actin-regulation, angiogenesis, and tissue-repair research models. It is not for human or veterinary use.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.