IGF-1 LR3 vs KPV
IGF-1 LR3 and KPV come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
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Last updated August 25, 2026
How do IGF-1 LR3 and KPV differ?
IGF-1 LR3 (Recombinant IGF-1 analog polypeptide) is catalogued under longevity & cellular research; KPV (Tripeptide alpha-MSH fragment) is catalogued under recovery & gut research. Verve lists 5 reported research applications for IGF-1 LR3 and 5 for KPV. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | IGF-1 LR3 | KPV |
|---|---|---|
| compound class | Recombinant IGF-1 analog polypeptide | Tripeptide alpha-MSH fragment |
| research area | longevity & cellular | recovery & gut |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 1mg · 2x 1mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $93.49 | $93.49 |
| availability | out of stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is IGF-1 LR3 and what is KPV?
IGF-1 LR3 is classified as Recombinant IGF-1 analog polypeptide; KPV as Tripeptide alpha-MSH fragment. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →KPV
Tripeptide alpha-MSH fragment
KPV is a tripeptide composed of lysine, valine, and proline, corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It is the smallest sequence retained from that parent peptide and is widely used as a compact reference compound in cellular signaling research, where its short chain length makes it convenient for controlled in-vitro work.
full KPV profile →Which research models is each compound studied in?
IGF-1 LR3 sits in longevity & cellular research and KPV in recovery & gut research, so their listed models largely do not intersect. The table lists 5 reported research applications for IGF-1 LR3 and 5 for KPV. Rows are per compound, not equivalences.
| IGF-1 LR3 — reported research applications | KPV — reported research applications |
|---|---|
| IGF-1 receptor binding and signal-transduction research | Inflammatory-signaling research models (NF-κB pathway studies) |
| PI3K/Akt and MAPK pathway research in cellular models | Cytokine-expression research in cultured cells |
| Cell-culture media supplementation for proliferation research | Melanocortin-receptor and alpha-MSH fragment research |
| IGFBP interaction and free-ligand availability studies | Epithelial and mucosal-barrier research models |
| Comparative analog research against native IGF-1 | Structure–activity studies of short peptide fragments |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for IGF-1 LR3 and KPV?
IGF-1 LR3 is listed from $93.49 and KPV from $93.49. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| IGF-1 LR3 | 1mg | $93.49 | out of stock |
| IGF-1 LR3 | 2x 1mg | $171.49 | out of stock |
| KPV | 10mg | $93.49 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about IGF-1 LR3 and KPV
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
What is KPV?
KPV is a tripeptide (lysine-valine-proline) corresponding to the C-terminal fragment of alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is KPV studied for in research?
In in-vitro and pre-clinical models it is used as a reference compound in inflammatory-signaling, cytokine-expression, and melanocortin-pathway research. Verve makes no claims about use in humans or animals.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.