KPV Research Peptide, US-Made & Third-Party Tested
✓ US-made · third-party tested · free US shipping over $100
last updated · reviewed by the verve research team
what is kpv?
KPV is a tripeptide (lysine-valine-proline) corresponding to the C-terminal fragment of alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use. It is catalogued under recovery & gut as a tripeptide alpha-msh fragment.
KPV is a tripeptide composed of lysine, valine, and proline, corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It is the smallest sequence retained from that parent peptide and is widely used as a compact reference compound in cellular signaling research, where its short chain length makes it convenient for controlled in-vitro work.
In the laboratory, KPV is studied in models of inflammatory signaling, including work on NF-κB pathway activity and cytokine expression in cultured cells, as well as in melanocortin-receptor and receptor-independent uptake research. Because reproducibility in this work depends on knowing exactly what is in the vial, verve manufactures KPV in the United States, screens every batch by HPLC to a 99%+ purity standard, and publishes a batch-level certificate of analysis.
kpv specifications
Reference data for KPV as supplied by verve for laboratory research use only.
| Compound | KPV |
|---|---|
| Compound class | Tripeptide alpha-MSH fragment |
| Research area | recovery & gut |
| Primary research focus | immune-signaling research |
| Purity standard | 99%+ purity standard, HPLC-verified per batch |
| Supplied as | Single research compound |
| Endotoxin-tested option | Available |
| Catalog sizes | 10mg |
| Catalog price | from $93 |
| Availability | In stock |
| Also supplied in | KLOW |
| Intended use | In-vitro laboratory research use only. Not for human or veterinary use. |
| Reference last reviewed |
what is kpv used for in research?
KPV is supplied strictly for laboratory research use only. Reported research contexts include:
- Inflammatory-signaling research models (NF-κB pathway studies)
- Cytokine-expression research in cultured cells
- Melanocortin-receptor and alpha-MSH fragment research
- Epithelial and mucosal-barrier research models
- Structure–activity studies of short peptide fragments
how pure is kpv?
purity, third-party testing & the certificate of analysis
Every batch of verve KPVis synthesized and vial-filled in the United States and screened by an independent, accredited laboratory. Chromatographic purity and quantity are measured by HPLC-UV/VIS; where the panel includes them, endotoxin is screened by LAL and sterility by USP <71>, with the sterility result reported as no growth detected or as pending while the culture is still running. Products are manufactured to a 99%+ purity standard where stated.
Published certificates for the lots currently in our COA library cover part of the range; a published report for this compound is not in the library yet. Orders placed Monday–Friday ship by 2pm CT, free over $100, with damage protection in transit and full US tracking.
KPV, explained in 60 secondsthe plain-english version — what it is, where it shows up, and the lab report behind the vialwhere to buy kpv for research
KPVrecovery & gutfrom $93browse all recovery & gut →kpv frequently asked questions
What is KPV?
KPV is a tripeptide (lysine-valine-proline) corresponding to the C-terminal fragment of alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is KPV studied for in research?
In in-vitro and pre-clinical models it is used as a reference compound in inflammatory-signaling, cytokine-expression, and melanocortin-pathway research. Verve makes no claims about use in humans or animals.
How does KPV relate to alpha-MSH?
KPV is the terminal three-residue sequence of alpha-melanocyte-stimulating hormone, which is why researchers use it to isolate the contribution of that fragment from the full-length parent peptide in laboratory models.
How pure is Verve's KPV, and is a COA included?
It is manufactured in the US to a 99%+ purity standard and verified by HPLC on every batch. Every order includes a downloadable batch-level COA, matched to the batch code on your vial.
kpv research references
- Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017;25(7):1628-1640.Examined nanoparticle delivery of the tripeptide and measured colonic inflammatory markers in a murine ulcerative colitis model.
- Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, et al. Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model. Cell Mol Gastroenterol Hepatol. 2016;2(3):340-357.Examined the role of the PepT1 transporter and KPV uptake in a murine colitis-associated cancer model.
- Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73.Characterised the mechanism of KPV action on inflammatory signalling in cultured human bronchial epithelial cells.
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-78.Examined PepT1 transporter-mediated cellular uptake of the tripeptide and measured pro-inflammatory cytokine expression in murine colitis models.
- Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(3):324-31.Examined inflammatory-signalling and histological endpoints for the alpha-MSH C-terminal fragment in two murine models of intestinal inflammation.
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US-made, third-party tested research peptides, every vial batch-traceable, every COA one click away.
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.