MOTS-C vs TB-500
MOTS-C and TB-500 come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do MOTS-C and TB-500 differ?
MOTS-C (Mitochondrial-derived 16-amino-acid peptide) is catalogued under weight & metabolic research; TB-500 (Thymosin β4 fragment · tissue-repair research) is catalogued under recovery & gut research. Verve lists 5 reported research applications for MOTS-C and 4 for TB-500. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | MOTS-C | TB-500 |
|---|---|---|
| compound class | Mitochondrial-derived 16-amino-acid peptide | Thymosin β4 fragment · tissue-repair research |
| research area | weight & metabolic | recovery & gut |
| reported research applications | 5 listed | 4 listed |
| supplied as | single compound | single compound |
| catalog sizes | 10mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $78.99 | $93.49 |
| availability | in stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is MOTS-C and what is TB-500?
MOTS-C is classified as Mitochondrial-derived 16-amino-acid peptide; TB-500 as Thymosin β4 fragment · tissue-repair research. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →TB-500
Thymosin β4 fragment · tissue-repair research
TB-500 is a synthetic 43-amino-acid peptide corresponding to an active fragment of thymosin beta-4, a naturally-occurring actin-binding protein. Verve supplies it as a high-purity research compound for tissue-repair and cellular research.
full TB-500 profile →Which research models is each compound studied in?
MOTS-C sits in weight & metabolic research and TB-500 in recovery & gut research, so their listed models largely do not intersect. The table lists 5 reported research applications for MOTS-C and 4 for TB-500. Rows are per compound, not equivalences.
| MOTS-C — reported research applications | TB-500 — reported research applications |
|---|---|
| Mitochondrial-derived peptide and retrograde-signaling research | Cell-migration research models |
| AMPK pathway research models | Actin-regulation and cytoskeletal research |
| One-carbon (folate–methionine) metabolism studies | Angiogenesis research |
| Cellular energy-metabolism and substrate-utilization research | Tissue-repair research models |
| Exercise-physiology and metabolic-stress research models | — |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for MOTS-C and TB-500?
MOTS-C is listed from $78.99 and TB-500 from $93.49. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| MOTS-C | 10mg | $78.99 | in stock |
| TB-500 | 10mg | $93.49 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about MOTS-C and TB-500
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
What is TB-500?
TB-500 is a synthetic 43-amino-acid peptide based on an active fragment of thymosin beta-4. Verve supplies it as a research compound for laboratory use only.
What is TB-500 studied for in research?
It is used in cell-migration, actin-regulation, angiogenesis, and tissue-repair research models. It is not for human or veterinary use.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.