MOTS-C vs Semax
MOTS-C and Semax come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do MOTS-C and Semax differ?
MOTS-C (Mitochondrial-derived 16-amino-acid peptide) is catalogued under weight & metabolic research; Semax (Synthetic heptapeptide · neuro research) is catalogued under mind & sleep research. Verve lists 5 reported research applications for MOTS-C and 4 for Semax. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | MOTS-C | Semax |
|---|---|---|
| compound class | Mitochondrial-derived 16-amino-acid peptide | Synthetic heptapeptide · neuro research |
| research area | weight & metabolic | mind & sleep |
| reported research applications | 5 listed | 4 listed |
| supplied as | single compound | single compound |
| catalog sizes | 10mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $78.99 | $64.99 |
| availability | in stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is MOTS-C and what is Semax?
MOTS-C is classified as Mitochondrial-derived 16-amino-acid peptide; Semax as Synthetic heptapeptide · neuro research. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →Semax
Synthetic heptapeptide · neuro research
Semax is a synthetic heptapeptide, a seven-amino-acid chain based on a fragment of adrenocorticotropic hormone, ACTH(4–10), with a C-terminal Pro-Gly-Pro extension added for stability. Verve supplies it as a high-purity research compound for neuroscience research.
full Semax profile →Which research models is each compound studied in?
MOTS-C sits in weight & metabolic research and Semax in mind & sleep research, so their listed models largely do not intersect. The table lists 5 reported research applications for MOTS-C and 4 for Semax. Rows are per compound, not equivalences.
| MOTS-C — reported research applications | Semax — reported research applications |
|---|---|
| Mitochondrial-derived peptide and retrograde-signaling research | Neurotrophic-signaling (BDNF) research |
| AMPK pathway research models | Neuroprotection research models |
| One-carbon (folate–methionine) metabolism studies | Cognitive-research models |
| Cellular energy-metabolism and substrate-utilization research | Peptide-stability research |
| Exercise-physiology and metabolic-stress research models | — |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for MOTS-C and Semax?
MOTS-C is listed from $78.99 and Semax from $64.99. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| MOTS-C | 10mg | $78.99 | in stock |
| Semax | 10mg | $64.99 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about MOTS-C and Semax
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
What is Semax?
Semax is a synthetic seven-amino-acid peptide derived from a fragment of ACTH. Verve supplies it as a research compound for laboratory use only.
What is Semax studied for in research?
It is used as a model neuropeptide in neurotrophic-signaling, neuroprotection, and cognitive research. It is not for human or veterinary use.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.