KPV vs MOTS-C
KPV and MOTS-C come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do KPV and MOTS-C differ?
KPV (Tripeptide alpha-MSH fragment) is catalogued under recovery & gut research; MOTS-C (Mitochondrial-derived 16-amino-acid peptide) is catalogued under weight & metabolic research. Verve lists 5 reported research applications for KPV and 5 for MOTS-C. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | KPV | MOTS-C |
|---|---|---|
| compound class | Tripeptide alpha-MSH fragment | Mitochondrial-derived 16-amino-acid peptide |
| research area | recovery & gut | weight & metabolic |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 10mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $93.49 | $78.99 |
| availability | in stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is KPV and what is MOTS-C?
KPV is classified as Tripeptide alpha-MSH fragment; MOTS-C as Mitochondrial-derived 16-amino-acid peptide. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
KPV
Tripeptide alpha-MSH fragment
KPV is a tripeptide composed of lysine, valine, and proline, corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It is the smallest sequence retained from that parent peptide and is widely used as a compact reference compound in cellular signaling research, where its short chain length makes it convenient for controlled in-vitro work.
full KPV profile →MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →Which research models is each compound studied in?
KPV sits in recovery & gut research and MOTS-C in weight & metabolic research, so their listed models largely do not intersect. The table lists 5 reported research applications for KPV and 5 for MOTS-C. Rows are per compound, not equivalences.
| KPV — reported research applications | MOTS-C — reported research applications |
|---|---|
| Inflammatory-signaling research models (NF-κB pathway studies) | Mitochondrial-derived peptide and retrograde-signaling research |
| Cytokine-expression research in cultured cells | AMPK pathway research models |
| Melanocortin-receptor and alpha-MSH fragment research | One-carbon (folate–methionine) metabolism studies |
| Epithelial and mucosal-barrier research models | Cellular energy-metabolism and substrate-utilization research |
| Structure–activity studies of short peptide fragments | Exercise-physiology and metabolic-stress research models |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for KPV and MOTS-C?
KPV is listed from $93.49 and MOTS-C from $78.99. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| KPV | 10mg | $93.49 | in stock |
| MOTS-C | 10mg | $78.99 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about KPV and MOTS-C
What is KPV?
KPV is a tripeptide (lysine-valine-proline) corresponding to the C-terminal fragment of alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is KPV studied for in research?
In in-vitro and pre-clinical models it is used as a reference compound in inflammatory-signaling, cytokine-expression, and melanocortin-pathway research. Verve makes no claims about use in humans or animals.
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.