Ipamorelin vs MOTS-C
Ipamorelin and MOTS-C come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do Ipamorelin and MOTS-C differ?
Ipamorelin (Synthetic pentapeptide secretagogue) is catalogued under longevity & cellular research; MOTS-C (Mitochondrial-derived 16-amino-acid peptide) is catalogued under weight & metabolic research. Verve lists 5 reported research applications for Ipamorelin and 5 for MOTS-C. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | Ipamorelin | MOTS-C |
|---|---|---|
| compound class | Synthetic pentapeptide secretagogue | Mitochondrial-derived 16-amino-acid peptide |
| research area | longevity & cellular | weight & metabolic |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 5mg · 10mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | available |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $64.99 | $78.99 |
| availability | out of stock | in stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is Ipamorelin and what is MOTS-C?
Ipamorelin is classified as Synthetic pentapeptide secretagogue; MOTS-C as Mitochondrial-derived 16-amino-acid peptide. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
Ipamorelin
Synthetic pentapeptide secretagogue
Ipamorelin is a synthetic pentapeptide and a selective growth-hormone secretagogue, meaning it is characterized in the literature as an agonist at the growth-hormone secretagogue receptor (GHS-R1a), the same receptor targeted by the endogenous ligand ghrelin. Its selectivity profile is the reason it is so frequently chosen as a reference agonist in receptor-signaling work.
full Ipamorelin profile →MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →Which research models is each compound studied in?
Ipamorelin sits in longevity & cellular research and MOTS-C in weight & metabolic research, so their listed models largely do not intersect. The table lists 5 reported research applications for Ipamorelin and 5 for MOTS-C. Rows are per compound, not equivalences.
| Ipamorelin — reported research applications | MOTS-C — reported research applications |
|---|---|
| GHS-R1a (ghrelin receptor) binding and agonist research | Mitochondrial-derived peptide and retrograde-signaling research |
| Secretagogue-pathway signal-transduction research | AMPK pathway research models |
| Comparative receptor-selectivity studies against non-selective secretagogues | One-carbon (folate–methionine) metabolism studies |
| Endocrine-signaling research models | Cellular energy-metabolism and substrate-utilization research |
| Peptide stability and structure–activity research | Exercise-physiology and metabolic-stress research models |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for Ipamorelin and MOTS-C?
Ipamorelin is listed from $64.99 and MOTS-C from $78.99. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| Ipamorelin | 5mg | $64.99 | out of stock |
| Ipamorelin | 10mg | $114.49 | out of stock |
| MOTS-C | 10mg | $78.99 | in stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about Ipamorelin and MOTS-C
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide characterized as a selective agonist at the growth-hormone secretagogue receptor (GHS-R1a). Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is Ipamorelin studied for in research?
It is used as a reference agonist in GHS-R1a receptor-binding and secretagogue-pathway signaling research in in-vitro and pre-clinical models. Verve makes no claims about effects in humans or animals.
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
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verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.