IGF-1 LR3 vs PT-141
IGF-1 LR3 and PT-141 come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do IGF-1 LR3 and PT-141 differ?
IGF-1 LR3 (Recombinant IGF-1 analog polypeptide) is catalogued under longevity & cellular research; PT-141 (Synthetic cyclic heptapeptide melanocortin agonist) is catalogued under skin & glow research. Verve lists 5 reported research applications for IGF-1 LR3 and 5 for PT-141. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | IGF-1 LR3 | PT-141 |
|---|---|---|
| compound class | Recombinant IGF-1 analog polypeptide | Synthetic cyclic heptapeptide melanocortin agonist |
| research area | longevity & cellular | skin & glow |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 1mg · 2x 1mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | not offered |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $93.49 | $50.49 |
| availability | out of stock | out of stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is IGF-1 LR3 and what is PT-141?
IGF-1 LR3 is classified as Recombinant IGF-1 analog polypeptide; PT-141 as Synthetic cyclic heptapeptide melanocortin agonist. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →PT-141
Synthetic cyclic heptapeptide melanocortin agonist
PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide analog of the melanocortin family, structurally related to alpha-melanocyte-stimulating hormone and to the earlier research analog Melanotan II. Verve supplies it as a high-purity research compound for laboratory melanocortin-receptor research.
full PT-141 profile →Which research models is each compound studied in?
IGF-1 LR3 sits in longevity & cellular research and PT-141 in skin & glow research, so their listed models largely do not intersect. The table lists 5 reported research applications for IGF-1 LR3 and 5 for PT-141. Rows are per compound, not equivalences.
| IGF-1 LR3 — reported research applications | PT-141 — reported research applications |
|---|---|
| IGF-1 receptor binding and signal-transduction research | Melanocortin-receptor (MC1R/MC3R/MC4R) binding research |
| PI3K/Akt and MAPK pathway research in cellular models | cAMP and G-protein-coupled receptor signaling assays |
| Cell-culture media supplementation for proliferation research | Receptor-selectivity and structure–activity profiling |
| IGFBP interaction and free-ligand availability studies | MC1R and melanogenesis research models in cell culture |
| Comparative analog research against native IGF-1 | Cyclic-peptide stability and conformation research |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for IGF-1 LR3 and PT-141?
IGF-1 LR3 is listed from $93.49 and PT-141 from $50.49. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| IGF-1 LR3 | 1mg | $93.49 | out of stock |
| IGF-1 LR3 | 2x 1mg | $171.49 | out of stock |
| PT-141 | 10mg | $50.49 | out of stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about IGF-1 LR3 and PT-141
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
What is PT-141?
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide melanocortin analog structurally related to alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is PT-141 studied for in research?
It is used as a reference agonist in melanocortin-receptor research, including MC1R, MC3R, and MC4R binding studies, cAMP signaling assays, and receptor-selectivity profiling. Verve makes no health claims.
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verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.