Melanotan I Research Peptide, US-Made & Third-Party Tested
✓ US-made · third-party tested · free US shipping over $100
last updated · reviewed by the verve research team
what is melanotan i?
Melanotan I (afamelanotide) is a synthetic tridecapeptide analog of alpha-melanocyte-stimulating hormone. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use. It is catalogued under skin & glow as a synthetic linear tridecapeptide.
Melanotan I, also known as afamelanotide, is a synthetic linear tridecapeptide and a structural analog of alpha-melanocyte-stimulating hormone (alpha-MSH), the endogenous ligand of the melanocortin receptor family. Substitutions to the native alpha-MSH sequence give the analog greater resistance to enzymatic degradation, which is why it is frequently selected as a stable reference ligand in melanocortin-pathway research.
In the laboratory, Melanotan I is studied as a melanocortin-1 receptor (MC1R) agonist model, including work on receptor binding and selectivity, cAMP second-messenger signaling, and melanogenesis in cultured melanocyte and cell-line systems. Verve manufactures Melanotan I in the United States, screens every batch by HPLC to a 99%+ purity standard, and publishes a batch-level certificate of analysis so results can be traced to an exact lot.
melanotan i specifications
Reference data for Melanotan I as supplied by verve for laboratory research use only.
| Compound | Melanotan I |
|---|---|
| Compound class | Synthetic linear tridecapeptide |
| Research area | skin & glow |
| Primary research focus | melanocortin-receptor research |
| Purity standard | 99%+ purity standard, HPLC-verified per batch |
| Supplied as | Single research compound |
| Endotoxin-tested option | Not offered |
| Catalog sizes | 10mg |
| Catalog price | from $65 |
| Availability | In stock |
| Intended use | In-vitro laboratory research use only. Not for human or veterinary use. |
| Reference last reviewed |
what is melanotan i used for in research?
Melanotan I is supplied strictly for laboratory research use only. Reported research contexts include:
- Melanocortin-1 receptor (MC1R) binding and selectivity research
- Melanogenesis research in cultured melanocyte models
- cAMP second-messenger signaling research
- Comparative alpha-MSH analog and receptor-agonist studies
- Peptide-stability and enzymatic-degradation research
how pure is melanotan i?
purity, third-party testing & the certificate of analysis
Every batch of verve Melanotan Iis synthesized and vial-filled in the United States and screened by an independent, accredited laboratory. Chromatographic purity and quantity are measured by HPLC-UV/VIS; where the panel includes them, endotoxin is screened by LAL and sterility by USP <71>, with the sterility result reported as no growth detected or as pending while the culture is still running. Products are manufactured to a 99%+ purity standard where stated.
Published certificates for the lots currently in our COA library cover part of the range; a published report for this compound is not in the library yet. Orders placed Monday–Friday ship by 2pm CT, free over $100, with damage protection in transit and full US tracking.
Melanotan I, explained in 60 secondsthe plain-english version — what it is, where it shows up, and the lab report behind the vialwhere to buy melanotan i for research
Melanotan Iskin & glowfrom $65browse all skin & glow →melanotan i frequently asked questions
What is Melanotan I?
Melanotan I (afamelanotide) is a synthetic tridecapeptide analog of alpha-melanocyte-stimulating hormone. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is Melanotan I studied for in research?
It is used as a reference MC1R agonist in melanocortin receptor-binding, cAMP signaling, and melanogenesis research models in cultured cells. Verve makes no claims about use in humans or animals.
How pure is Verve's Melanotan I?
It is manufactured in the US, verified to a 99%+ purity standard by HPLC on every batch, and third-party tested, with a batch COA on every order.
Is a certificate of analysis included?
Yes, every order includes a downloadable batch-level COA. Match the batch code on your vial to the row in the COA library to read the report for your exact lot.
melanotan i research references
- Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, et al. Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor. Cell Res. 2021;31(10):1061-1071.Structural study of the human melanocortin-1 receptor characterising calcium-mediated ligand recognition and G-protein interaction.
- Sawyer TK, Sanfilippo PJ, Hruby VJ, Engel MH, Heward CB, Burnett JB, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A. 1980;77(10):5754-8.Original synthesis and bioassay characterisation of the [Nle4, D-Phe7]-alpha-MSH analogue, reporting melanotropic potency and duration of activity relative to native alpha-MSH.
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purity, proven.
US-made, third-party tested research peptides, every vial batch-traceable, every COA one click away.
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.