MOTS-C vs PT-141
MOTS-C and PT-141 come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
Last updated August 25, 2026
How do MOTS-C and PT-141 differ?
MOTS-C (Mitochondrial-derived 16-amino-acid peptide) is catalogued under weight & metabolic research; PT-141 (Synthetic cyclic heptapeptide melanocortin agonist) is catalogued under skin & glow research. Verve lists 5 reported research applications for MOTS-C and 5 for PT-141. Both are made in the United States, screened by HPLC to a 99%+ purity standard, and shipped with a batch-level certificate of analysis.
| field | MOTS-C | PT-141 |
|---|---|---|
| compound class | Mitochondrial-derived 16-amino-acid peptide | Synthetic cyclic heptapeptide melanocortin agonist |
| research area | weight & metabolic | skin & glow |
| reported research applications | 5 listed | 5 listed |
| supplied as | single compound | single compound |
| catalog sizes | 10mg | 10mg |
| purity standard | 99%+ by HPLC | 99%+ by HPLC |
| manufactured | United States | United States |
| batch COA | published per lot | published per lot |
| endotoxin-tested option | available | not offered |
| co-formulated together in | not co-formulated | not co-formulated |
| price from | $78.99 | $50.49 |
| availability | in stock | out of stock |
Prices and stock read live from the catalog. Both compounds are supplied strictly as reference materials for in-vitro laboratory research.
What is MOTS-C and what is PT-141?
MOTS-C is classified as Mitochondrial-derived 16-amino-acid peptide; PT-141 as Synthetic cyclic heptapeptide melanocortin agonist. Both profiles below cover scientific identity only — what the molecule is and which laboratory models it appears in. Verve supplies both strictly as in-vitro reference materials, and neither profile describes human or veterinary use.
MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →PT-141
Synthetic cyclic heptapeptide melanocortin agonist
PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide analog of the melanocortin family, structurally related to alpha-melanocyte-stimulating hormone and to the earlier research analog Melanotan II. Verve supplies it as a high-purity research compound for laboratory melanocortin-receptor research.
full PT-141 profile →Which research models is each compound studied in?
MOTS-C sits in weight & metabolic research and PT-141 in skin & glow research, so their listed models largely do not intersect. The table lists 5 reported research applications for MOTS-C and 5 for PT-141. Rows are per compound, not equivalences.
| MOTS-C — reported research applications | PT-141 — reported research applications |
|---|---|
| Mitochondrial-derived peptide and retrograde-signaling research | Melanocortin-receptor (MC1R/MC3R/MC4R) binding research |
| AMPK pathway research models | cAMP and G-protein-coupled receptor signaling assays |
| One-carbon (folate–methionine) metabolism studies | Receptor-selectivity and structure–activity profiling |
| Cellular energy-metabolism and substrate-utilization research | MC1R and melanogenesis research models in cell culture |
| Exercise-physiology and metabolic-stress research models | Cyclic-peptide stability and conformation research |
Research contexts only. Both compounds are supplied for laboratory research use only, and no entry above describes an effect in humans or animals.
What sizes and prices does verve list for MOTS-C and PT-141?
MOTS-C is listed from $78.99 and PT-141 from $50.49. The table below is every catalog size verve currently lists for the two compounds, at single-vial prices before the automatic multi-compound discount. Sizes describe the vial format supplied to the laboratory, nothing more.
| compound | size listed | price | availability |
|---|---|---|---|
| MOTS-C | 10mg | $78.99 | in stock |
| PT-141 | 10mg | $50.49 | out of stock |
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
shop the compounds →Frequently asked questions about MOTS-C and PT-141
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
What is PT-141?
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide melanocortin analog structurally related to alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is PT-141 studied for in research?
It is used as a reference agonist in melanocortin-receptor research, including MC1R, MC3R, and MC4R binding studies, cAMP signaling assays, and receptor-selectivity profiling. Verve makes no health claims.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.